1/16 Mônaco x Club Brugge, 06/11 as 15h55, no Louis II 2/16 Estrela Vermelha x Liverpool, 06/11 as 15h55, no Stadion Rajko Mitic 3/16 Atlético de Madrid x Borussia Dortmund, 06/11 as 18 horas, no Wanda Metropolitano 4/16 Internazionale x Barcelona, 06/11 as 18 horas, no Giuseppe Meazza 5/16 Tottenham x PSV Eindhoven, 06/11 as 18 horas, em Wembley 6/16 Napoli x Paris Saint-Germain, 06/11 as 18 horas, no San Paolo 7/16 Schalke 04 x Galatasaray, 06/11 as 18 horas, na Veltins Arena 8/16 Porto x Lokomotiv Moscou, 06/11 as 18 horas, no Estádio Do Dragão 9/16 CSKA Moscou x Roma, 07/11 as 15h55, no CSKA Stadium 10/16 Valencia x Young Boys, 07/11 as 15h55, no Mestalla 11/16 Benfica x Ajax, 07/11 as 18 horas, no Estádio da Luz 12/16 Bayern x AEK Atenas, 07/11 as 18 horas, na Allianz Arena 13/16 Manchester City x Shakhtar Donetsk, 07/11 as 18 horas, no Etihad Stadium 14/16 Lyon x Hoffenheim, 07/11 as 18 horas, no Groupama Stadium 15/16 Viktoria Plzen x Real Madrid, 07/11 as 18 horas, no Doosan Arena 16/16 Juventus x Manchester United, 07/11 as 18 horas, no Juventus Stadium