1/16 Hoffenheim x Manchester City, 02/10 as 13h55, na Rhein Neckar Arena 2/16 Juventus x Young Boys, 02/10 as 13h55, no Juventus Stadium 3/16 AEK Atenas x Benfica, 02/10 as 16 horas, no Spiros Louis 4/16 Bayern x Ajax, 02/10 as 16 horas, no Allianz Arena 5/16 Lyon x Shakhtar Donetsk, 02/10 as 16 horas, no Groupama Stadium 6/16 Roma x Viktoria Plzen, 02/10 as 16 horas, no Olímpico de Roma 7/16 CSKA Moscou x Real Madrid, 02/10 as 16 horas, no CSKA Stadium 8/16 Manchester United x Valencia, 02/10 as 16 horas, no Old Trafford 9/16 Paris Saint Germain x Estrela Vermelha, 03/10 as 13h55, no Parque dos Príncipes 10/16 Lokomotiv Moscou x Schalke 04, 03/10 as 13h55, no Lokomotiv Stadium 11/16 Borussia Dortmund x Monaco, 03/10 as 16 horas, no Signal Iduna Park 12/16 Atlético de Madrid x Club Brugge, 03/10 as 16 horas, no Wanda Metropolitano 13/16 PSV Eindhoven x Internazionale, 03/10 as 16 horas, no PSV Stadion 14/16 Tottenham x Barcelona, 03/10 as 16 horas, no estádio de Wembley 15/16 Napoli x Liverpool, 03/10 as 16 horas, no San Paolo 16/16 Porto x Galatasaray, 03/10 as 16 horas, no estádio do Dragão